Current Members | Former Members | Principal Investigator Vamsi K. Mootha, MD Associate Professor Department of Systems Biology, Harvard Medical School Department of Medicine, Massachusetts General Hospital Senior Associate Member Broad Institute of MIT and Harvard B.S., Stanford University M.D., Harvard Medical School Joined the Harvard Faculty in 2004 Click here to email Vamsi. Vamsi Mootha is an Associate Professor of Systems Biology and of Medicine at Harvard Medical School. His laboratory is based at the Center for Human Genetic Research at Massachusetts General Hospital and at the Broad Institute of MIT and Harvard. He is board certified in internal medicine and specializes in rare mitochondrial diseases. His laboratory uses a blend of genomics, computation, and biochemical physiology to systematically study mitochondrial biology. Dr. Mootha received his B.S. (with honors, with distinction) in Mathematical and Computational Science at Stanford University. He then received his M.D. (cum laude) from the Harvard-MIT Division of Health Sciences and Technology, where his thesis research focused on mitochondrial energetics. Following an internship and residency in Internal Medicine at Brigham and Women’s Hospital, he pursued postdoctoral training in Eric Lander’s laboratory at the Whitehead Institute, where he applied the new tools of genomics to study mitochondrial biology. His research group consists of clinicians, computer scientists, and biologists, who work collaboratively to elucidate the network properties of mitochondria, and how these properties go awry in human disease. His work has led to the discovery of three genes underlying devastating human metabolic diseases, as well as to the discovery that mitochondrial dysfunction is associated with the common form of type 2 diabetes mellitus. His work has also led to the development of generic, computational strategies that have now been applied successfully to other human diseases. Dr. Mootha has received a number of honors, including election to Phi Beta Kappa, an HHMI Physician Postdoctoral Fellowship, a Burroughs Wellcome Career Award in the Biomedical Sciences, a Culpeper Scholarship in the Clinical Sciences, an HHMI Early Physician Scientist Award, a MacArthur Foundation Fellowship, and the Judson Daland Prize of the American Philosophical Society.