2008
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK.
Molecular Systems Biology doi:10.1038/msb.2008.50.
A mitochondrial protein compendium elucidates complex I disease biology
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK.
Cell 134:112-23.
Large-scale chemical dissection of mitochondrial function
Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK.
Nature Biotechnology 26:343-51.
2007
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver, P.
Nature Nov 29; 450: 736-40.
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.
Journal of Clinical Investigation Nov; 117: 3463-74.
TXNIP regulates peripheral glucose metabolism in humans
Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Björnholm M, Tornqvist H, Zierath JR, Ridderstråle M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK.
PLoS Medicine 4:e158.
 
2006
Buffering mitochondrial DNA variation
Baughman JM, Mootha VK.
Nature Genetics 38:1232-3.
Mitochondrial Endocrinology
Yialamas M, Groop LC, Mootha VK.
Textbook of Mitochondrial Medicine (eds: S. DiMauro, E. Schon, M. Hirano).
Comprehensive association testing of common mitochondrial DNA variation in metabolic disease
Saxena R, Bakker PD, Singer K, Mootha VK, Burtt N, Hirschhorn JN, Gaudet D, Daly MJ, Groop LC, Ardlie KG, Altshuler D.
American Journal of Human Genetics 79:54-61.
The Mpv17 gene encodes a protein of the inner mitochondrial membrane and is mutated in infantile hepatic mitochondrial DNA depletion
Spinazzola A, Viscomi C, Fernandez-Vizarra E, Carrara C, D’Adamo P, Calvo S, Marsano RM, Donnini C, Weiher H, Strisciuglio P, Parini R, Sarzi E, Chan A, DiMauro S, Rötig A, Gasparini P, Ferrero I, Mootha VK, Tiranti V, Zeviani M.
Nature Genetics 38:570-575.
Systematic identification of human mitochondrial disease genes through integrative genomics
Calvo S, Jain M, XieX , Sheth SA, Goldberger O, Chang B, Spinazzola A, Zeviani M, Carr SA, Mootha VK.
Nature Genetics 38:576-582.
A mammalian organelle map by protein correlation profiling
Foster LJ, de Hoog CL, Xie X, Mootha VK, Mann M.
Cell 125:187-99.
 
2005
Systematic discovery of regulatory motifs in human promoters and 3’ UTRs by comparison of several mammals
Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M.
Nature 434:338-45.
Disease gene discovery through integrative genomics
Giallourakis C, Henson C, Reich M, Xie X, Mootha VK.
Annual Review of Genomics and Human Genetics 6:381-406.
Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, Yialamas M, Groop L, Elahi D, Hayes FJ.
Diabetes Care. 28:1636-42.
Estrogen-related receptor α (ERRα): A novel target in type 2 diabetes
Handschin C, Mootha VK.
Drug Discovery Today: Therapeutic Strategies Vol 2; Summer 2005: 151-56.
Gene set enrichment analysis: A knowledge-based approach for interpreting genomewide expression profiles
Subramanian AS, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP.
Proceedings of the National Academy of Sciences U.S.A., 102:15545-50.
 
2004
Errα and Gabpa/b specify PGC-1α dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
Mootha VK, Handschin C, Arlow D, Xie X, St-Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, ES Lander, Spiegelman BM.
Proceedings of the National Academy of Sciences U.S.A., 101(17):6570-5.
A novel mitochondrial tRNAPhe mutation causes MERRF syndrome
Mancuso M, Filosto M, Mootha VK, Rocchi A, Pistolesi S, Murri L, DiMauro S, Siciliano G.
Neurology 62(11):2119-21.
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice
Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.
Cell 119:121-35.
Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation
Quinzii CM, Kattah AG, Naini A, Akman HO, Mootha VK, SM DiMauro, Hirano M.
Neurology 64(3):539-41.
 
2003
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Zhu F, Mitchell GA, Morin C, Mann M, Hudson TJ, Robinson B, Rioux JD, Lander ES.
Proceedings of the National Academy of Sciences U.S.A., 100(2):  605-610.
PGC-1α responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman BM, Lander ES, Hirschhorn JN, Altshuler D, Groop LC.
Nature Genetics 34(3):267-73.
Integrated analysis of protein expression, tissue diversity, and gene regulation in mouse mitochondria
Mootha VK, Bunkenborg J, Olsen J, Hjerrild M, Wisniewski JR, Stahl E, Bolouri M, Ray H, Sihag S, Kamal M, Patterson N, Lander ES, Mann M.
Cell 115(5):629-40.
 
2001
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1
Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang C, Krauss S, Mootha VK, Lowell BB, Spiegelman BM.
Molecular Cell, 8:  971-982.
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c
Mootha VK, Wei MC, Buttle K, Scorrano L, Panoutsakopoulou V, Korsmeyer SJ.
The EMBO Journal 20(4):661-671.
2000
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ.
Genes & Development, 14:2060-2071.
Pheochromocytoma induced cardiomyopathy
Mootha VK, Feldman J, Mannting F, Winters GL, Johnson W.
Circulation, 102(4):  E11-E13.
Energy metabolism in uncoupling protein 3 gene knockout mice
Vidal-Puig AJ, Grujic D, Zhang C, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB.
Journal of Biological Chemistry, 274(21):16258-16266.
Ca2+ activation of heart mitochondrial oxidative phosphorylation:  role of the F0/F1-ATPase
Territo PR, Mootha VK, French SA, Balaban RS.
American Journal of Physiology 278:  C423-C434.
 
1999
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic activator PGC-1
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM.
Cell 98(1):  115-124.
Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
Zhang CY, Hagen T, Mootha VK, Slieker LJ, Lowell BB.
FEBS Letters 449:  129-134.
 
1997
Maximum oxidative phosphorylation capacity of the mammalian heart
Mootha VK, Arai A, Balaban RS.
American Journal of Physiology 272:  H769-H775.
 
1996
Spectroscopic determination of cytochrome oxidase content in tissues containing myoglobin or hemoglobin
Balaban RS, Mootha VK, Arai A.
Analytical Biochemistry 237:  274-278.
Neutral carrier based ‘Ca2+-selective’ microelectrodes for the measurement of tetraphenylphosphonium
Mootha VK, French S, Balaban RS.
Analytical Biochemistry 236:  327-330.
 

 

 

  

 
     
   
     
     
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