2014
Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans
Lennerz B, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, Mootha VK.
Molecular Genetics and Metabolism: in press.
Directed evolution of APEX2 for electron microscopy and proximity labeling
Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY.
Nature Methods: in press.
Biochemical Characterization of Pathogenic Mutations in Human Mitochondrial Methionyl-tRNA Formyltransferase
Sinha A, Kohrer C, Weber MH, Masuda I, Mootha VK, Hou YM, RajBhandary UL.
J Biol Chem: in press.
Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominany mitochondrial myopathy
Ajroud-Driss S, Fecto F, Arjoud K, Lalani I, Calvo SE, Mootha VK, Deng HX, Siddique N, Tahmoush AJ, Heiman-Patterson TD, Siddique T.
Neurogenetics: in press.
Expansion of biological pathways based on evolutionary inference
Li Y, Calvo SE, Gutman R, Liu JS, Mootha VK.
Cell: 158(1):213-25.
Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging
Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY.
Mol Cell: 55(2):332-41.
Reconstitution of the mitochondrial calcium uniporter in yeast
Kovacs-Bogdan E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK.
Proc Natl Acad Sci.: 111(24):8985-90.
Functional genomic analysis of human mitochondrial RNA processing
Wolf AR, Mootha VK.
Cell Rep: 7(3):918-31.
The uniporter: From newly identified parts to function
Kamer KJ, Sancak Y, Mootha VK.
Biochem Biophys Res Commun.: 449(4):370-2.
A systematic survey of lipids across mouse tissues
Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R.
Am J Physiol Endocrinol Metab.: 306(8):E854-68.
Next generation sequencing with copy number variant detection expands the phenotypic spectrum of HSD17B4-deficiency
Lieber DS, Hershman SG, Slate NG, Calvo SE, Sims KB, Schmahmann JD, Mootha VK.
BMC Med Genet.: 15:30.
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter
Kamer KJ, Mootha VK.
EMBO Rep.: 15(3):299-307.
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK.
Nat Commun.: 5:3128
CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity
Strittmatter L, Li Y, Nakatsuka NJ, Calvo SE, Grabarek Z, Mootha VK.
Hum Mol Genet: 23(9):2313-23.
 
2013
A Common Pathway for a Rare Disease?
Vafai SB, Mootha VK.
Science: 342(6165):1453-54.
EMRE is an essential component of the mitochondrial calcium uniporter complex
Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.
Science: 342(6164):1379-82.
Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4
Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE Jr, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, Dimauro S, Paw BH.
Am J Hum Genet.: 93(5):906-14
Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism
Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK.
J Biol Chem: 288(49): 35387-95.
Distilling pathophysiology from complex disease genetics
Chakravarti A, Clark AG, Mootha VK.
Cell: 155(1):21-6.
Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes
Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, Degennaro C, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG.
Human Molecular Genetics:(22):4460-4473.
New treatments for mitochondrial disease-no time to drop our standards
Pfeffer G, Horvath R, Klopstock T, Mootha VK, Suomalainen A, Koene S, Hirano M, Zeviani M, Bindoff LA, Yu-Wai-Man P, Hanna M, Carelli V, McFarland R, Majamaa K, Turnbull DM, Smeitink J, Chinnery PF.
Nature Reviews Neurology: (8):474-81.
Mitochondrial encephalomyopathy due to a novel mutation in ACAD9
Garone C, Donati MA, Sacchini M, Garcia-Diaz B, Bruno C, Calvo S, Mootha VK, Dimauro S.
JAMA Neurology: 70(9):1177-9.
MCU encodes the pore conducting mitochondrial calcium currents
Chaudhuri D, Sancak Y, Mootha VK, Clapham DE.
Elife
: 2:e00704
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2+) uniporter
Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, Perez Sde L, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G.
Cell Metabolism
: 17(6):976-87.
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling
Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, OShea J, Koteliansky V, Mootha VK
PLoS One
: 8(2):e55785.
Targeted exome sequencing of suspected mitochondrial disorders
Lieber DS, Calvo SE, Shanahan K, Slate NG, Liu S, Hershman SG, Gold NB, Chapman BA, Thorburn DR, Berry GT, Schmahmann JD, Borowsky ML, Mueller DM, Sims KB, Mootha VK
Neurology: 80(19):1762-1770
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging
Rhee HW, Zou P, Udeshi ND, Martell JD, Mootha VK, Carr SA, Ting AY
Science
: 339(6125):1328-31.
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease
Kornblum C, Nicholls TJ, Haack TB, Schöler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, Quinzii CM, Dimauro S, Calvo SE, Mootha VK, Klopstock T, Strom TM, Meitinger T Minczuk M, Kunz WS, Prokisch H.
Nature Genetics
: 45(2):214-9.
Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis
Rensvold JW, Ong SE, Jeevananthan A, Carr SA, Mootha VK, Pagliarini DJ.
Cell Reports: 3(1):237-45.
 
2012
Mitochondrial disorders as windows into an ancient organelle
Vafai SB, Mootha VK.
Nature
: 491(7424):374-383.
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy
Martell JD, Deerinck TJ, Sancak Y, Poulos TL, Mootha VK, Sosinsky GE, Ellisman MH, Ting AY.
Nature Biotechnology: 30(11):1143-1148.
Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions
Ronchi D, Garone C, Bordoni A, Gutierrez Rios P, Calvo SE, Ripolone M, Ranieri M, Rizzuti M, Villa L, Magri F, Corti S, Bresolin N, Mootha VK, Moggio M, Dimauro S, Comi GP, Sciacco M.
Brain: 135(11):3404-3415.
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham De, Spiegelman BM.
Cell: 151(1):96-110.
MPV17 mutations causing adult-onset multisystemic disorder with multple mitochondrial DNA deletions
Garone C, Rubio JC, Calvo SE, Naini A, Tanji K, Dimauro S, Mootha VK, Hirano M.
Archives of Neurology: 69(12):1648-1651.
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents
McCormack SE, Shaham O, McCarthy MA, Deik AA, Wang TJ, Gerszten RE, Clish CB, Mootha VK, Grinspoon SK, Fleischman A.
Pediatric Obesity: 8(1):52-61.
Metabolite profiling reveals a key role for glycine in rapid cancer cell proliferation
Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza A, Kafri R, Kirschner MW, Clish CB, Mootha VK.
Science: 336(6084):1040-1044.
Evolutionary diversity of the mitochondrial calcium uniporter
Bick AG, Calvo SE, Mootha VK.
Science: 336(6083):86
A chemical screen probing the relationship between mitochondral content and cell size
Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK.
PLoS ONE, 7(3):e33755.
Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing
Calvo SE, Compton AG, Hershman SG, Lim SC, Lieber DS, Tucker EJ, Laskowski A, Garone C, Liu S, Jaffe DB, Christodoulou J, Fletcher JM, Bruno DL, Goldblatt J, DiMauro S, Thorburn DR, Mootha VK.
Science Translational Medicine, 4(118):118ra10.
Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease
Lieber DS, Vafai SB, Horton LC, Slate NG, Liu S, Borowsky ML, Calvo SE, Schmahmann JD, Mootha VK.
BMC Medical Genetics, 13(1):3.
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations
Leoni V, Strittmatter L, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V.
Molecular Genetics and Metabolism, 105(3):463-71.
 
2011
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation
Tucker EJ, Hershman SG, Kohrer C, Belcher-Timme CA, Patel J, Goldberger OA, Christodoulou J, Silberstein JM, McKenzie M, Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, Mootha VK.
Cell Metabolism, 14(3):428-34.
A small-molecule screening strategy to identify suppressors of statin myopathy
Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK.
ACS Chemical Biology, 6(9):900-04.
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
Baughman J, Perocchi F, Girgis H, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK.
Nature, 476(7360):341-5.
Metabolite profiles and the risk of developing diabetes
Wang T, Larson MG, Ramachandran VS, Cheng S, Rhee EP, McCabe E, Lewis GD, Foz CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE.
Nature Medicine, 17(4):448-53.
2010
Meclizine is neuroprotective in models of Huntington's disease
Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha, VK.
Human Molecular Genetics, 20(2):294-300.
FOXRED1, encoding a FAD-dependent oxidoreductase complex-I specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy
Fassone E, Duncan AJ, Taanman JW, Pagnamenta AT, Sadowski MI, Holand T, Qasim W, Rutland P, Calvo SE, Mootha VK, Bitner-Glindizicz M, Rahman S.
Human Molecular Genetics, 19(24):4837-47.
High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency
Calvo SE, Tucker EJ, Compton AG, Kirby DM, Crawford G, Burtt NP, Rivas M, Guiducci C, Bruno DL, Goldberger O, Redman MC, Wiltshire E, Wilson CJ, Altshuler D, Gabriel SB, Daly MJ, Thorburn DR, Mootha VK.
Nature Genetics, 42(10):851-8.
Common inherited variation in mitochondrial genes is not enriched for associations with Type 2 Diabetes or related glycemic traits
Segre AV, DIAGRAM Consortium, MAGIC investigators, Leif Groop, Mootha VK, Daly MJ, Altshuler D.
PLoS Genetics, 6(8):e1001058
MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake
Perocchi F, Gohil VK, Girgis H, Bao R., McCombs JE, Palmer AE, Mootha VK.
Nature, 467(7313):291-6.
The mitochondrial proteome and human disease
Calvo SE, Mootha VK.
Annual Review of Genomics and Human Genetics, 11:25-44.
Mitochondrial and nuclear genomic responses to loss of LRPPRC expression
Gohil VM, Nilsson R, Belcher-Timme CA, Luo B, Root DE, Mootha VK.
Journal of Biological Chemistry, 285(18):13742-7.
The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functions
Charest-Marcotte A, Dufour C, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguere V.
Genes & Development, 10:537-542.
Propranolol and the risk of hospitalized myopathy: Translating chemical genomics findings into population-level hypotheses
Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J.
American Heart Journal, 159:428-33.
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK.
Nature Biotechnology, 28(3):249-55.
Inborn variation in metabolism
Mootha VK, Hirschhorn JN.
Nature Genetics. 42(2):97-8.
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells
Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK.
Proceedings of the National Academy of Sciences U.S.A. 107(4):1571-5.
2009
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis
Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, Mootha VK.
Cell Metabolism 10:119-30.
A computational screen for regulators of oxidative phosphorylation Implicates SLIRP in mitochondrial RNA homeostasis
Baughman JM, Nilsson R, Gohil VM, Arlow DH, Gauhar Z, Mootha VK.
PLoS Genetics 5(8): e10000590.
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
Calvo SE, Pagliarini DJ, Mootha VK.
Proceedings of the National Academy of Sciences U.S.A. 106(18):7507-12.
2008
Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease
Sugiana C, Pagliarini DJ, McKenzie M, Kirby DM, Salemi R, Abu-Amero KK, Dahl HM, Hutchison WM, Vascotto KA, Smith SM, Newbold RF, Christodoulou J, Calvo S, Mootha VK, Ryan MT, Thorburn DR.
American Journal of Human Genetics 83:468-78.
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK.
Molecular Systems Biology 4:214.
A mitochondrial protein compendium elucidates complex I disease biology
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK.
Cell 134:112-23.
Large-scale chemical dissection of mitochondrial function
Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK.
Nature Biotechnology 26:343-51.
2007
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver, P.
Nature Nov 29; 450: 736-40.
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.
Journal of Clinical Investigation Nov; 117: 3463-74.
TXNIP regulates peripheral glucose metabolism in humans
Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Björnholm M, Tornqvist H, Zierath JR, Ridderstråle M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK.
PLoS Medicine 4:e158.
 
2006
Buffering mitochondrial DNA variation
Baughman JM, Mootha VK.
Nature Genetics 38:1232-3.
Mitochondrial Endocrinology
Yialamas M, Groop LC, Mootha VK.
Textbook of Mitochondrial Medicine (eds: S. DiMauro, E. Schon, M. Hirano).
Comprehensive association testing of common mitochondrial DNA variation in metabolic disease
Saxena R, Bakker PD, Singer K, Mootha VK, Burtt N, Hirschhorn JN, Gaudet D, Daly MJ, Groop LC, Ardlie KG, Altshuler D.
American Journal of Human Genetics 79:54-61.
The Mpv17 gene encodes a protein of the inner mitochondrial membrane and is mutated in infantile hepatic mitochondrial DNA depletion
Spinazzola A, Viscomi C, Fernandez-Vizarra E, Carrara C, D’Adamo P, Calvo S, Marsano RM, Donnini C, Weiher H, Strisciuglio P, Parini R, Sarzi E, Chan A, DiMauro S, Rötig A, Gasparini P, Ferrero I, Mootha VK, Tiranti V, Zeviani M.
Nature Genetics 38:570-575.
Systematic identification of human mitochondrial disease genes through integrative genomics
Calvo S, Jain M, XieX , Sheth SA, Goldberger O, Chang B, Spinazzola A, Zeviani M, Carr SA, Mootha VK.
Nature Genetics 38:576-582.
A mammalian organelle map by protein correlation profiling
Foster LJ, de Hoog CL, Xie X, Mootha VK, Mann M.
Cell 125:187-99.
 
2005
Systematic discovery of regulatory motifs in human promoters and 3’ UTRs by comparison of several mammals
Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M.
Nature 434:338-45.
Disease gene discovery through integrative genomics
Giallourakis C, Henson C, Reich M, Xie X, Mootha VK.
Annual Review of Genomics and Human Genetics 6:381-406.
Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, Yialamas M, Groop L, Elahi D, Hayes FJ.
Diabetes Care. 28:1636-42.
Estrogen-related receptor α (ERRα): A novel target in type 2 diabetes
Handschin C, Mootha VK.
Drug Discovery Today: Therapeutic Strategies Vol 2; Summer 2005: 151-56.
Gene set enrichment analysis: A knowledge-based approach for interpreting genomewide expression profiles
Subramanian AS, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP.
Proceedings of the National Academy of Sciences U.S.A., 102:15545-50.
 
2004
Errα and Gabpa/b specify PGC-1α dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
Mootha VK, Handschin C, Arlow D, Xie X, St-Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, ES Lander, Spiegelman BM.
Proceedings of the National Academy of Sciences U.S.A., 101(17):6570-5.
A novel mitochondrial tRNAPhe mutation causes MERRF syndrome
Mancuso M, Filosto M, Mootha VK, Rocchi A, Pistolesi S, Murri L, DiMauro S, Siciliano G.
Neurology 62(11):2119-21.
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice
Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.
Cell 119:121-35.
Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation
Quinzii CM, Kattah AG, Naini A, Akman HO, Mootha VK, SM DiMauro, Hirano M.
Neurology 64(3):539-41.
 
2003
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Zhu F, Mitchell GA, Morin C, Mann M, Hudson TJ, Robinson B, Rioux JD, Lander ES.
Proceedings of the National Academy of Sciences U.S.A., 100(2):  605-610.
PGC-1α responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman BM, Lander ES, Hirschhorn JN, Altshuler D, Groop LC.
Nature Genetics 34(3):267-73.
Integrated analysis of protein expression, tissue diversity, and gene regulation in mouse mitochondria
Mootha VK, Bunkenborg J, Olsen J, Hjerrild M, Wisniewski JR, Stahl E, Bolouri M, Ray H, Sihag S, Kamal M, Patterson N, Lander ES, Mann M.
Cell 115(5):629-40.
 
2001
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1
Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang C, Krauss S, Mootha VK, Lowell BB, Spiegelman BM.
Molecular Cell, 8:  971-982.
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c
Mootha VK, Wei MC, Buttle K, Scorrano L, Panoutsakopoulou V, Korsmeyer SJ.
The EMBO Journal 20(4):661-671.
2000
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ.
Genes & Development, 14:2060-2071.
Pheochromocytoma induced cardiomyopathy
Mootha VK, Feldman J, Mannting F, Winters GL, Johnson W.
Circulation, 102(4):  E11-E13.
Energy metabolism in uncoupling protein 3 gene knockout mice
Vidal-Puig AJ, Grujic D, Zhang C, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB.
Journal of Biological Chemistry, 274(21):16258-16266.
Ca2+ activation of heart mitochondrial oxidative phosphorylation:  role of the F0/F1-ATPase
Territo PR, Mootha VK, French SA, Balaban RS.
American Journal of Physiology 278:  C423-C434.
 
1999
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic activator PGC-1
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM.
Cell 98(1):  115-124.
Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
Zhang CY, Hagen T, Mootha VK, Slieker LJ, Lowell BB.
FEBS Letters 449:  129-134.
 
1997
Maximum oxidative phosphorylation capacity of the mammalian heart
Mootha VK, Arai A, Balaban RS.
American Journal of Physiology 272:  H769-H775.
 
1996
Spectroscopic determination of cytochrome oxidase content in tissues containing myoglobin or hemoglobin
Balaban RS, Mootha VK, Arai A.
Analytical Biochemistry 237:  274-278.
Neutral carrier based ‘Ca2+-selective’ microelectrodes for the measurement of tetraphenylphosphonium
Mootha VK, French S, Balaban RS.
Analytical Biochemistry 236:  327-330.
 

 

 

 

 

     
   
     
     
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